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From The Free On-line Dictionary of Computing (05 January 2017) [foldoc]:
16450
A UART with a one-byte FIFO buffer. The 16450
is a higher speed, fixed version of the 8250. It was
superseded by the 16550.
The 16450 was used for the IBM PC AT and PS/2 but will not
work in a IBM PC XT.
(2004-03-21)